Aberrant DNA methylation of genomic regions translocated in myeloid malignancies.
Leuk Lymphoma
; 30(1-2): 1-9, 1998 Jun.
Article
in En
| MEDLINE
| ID: mdl-9669671
ABSTRACT
The mechanism of aberrant genetic recombinatorial events in neoplasia is vaguely understood. One hypothesis is that aberrant DNA methylation may in some way predispose genomic regions to recombination. Using the t(9;22) of chronic myeloid leukemia (CML) and the t(15;17) of acute promyelocytic leukemia (APL) as models, our laboratory and others have gathered data supporting this hypothesis. These data are reviewed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Recombination, Genetic
/
Translocation, Genetic
/
Leukemia, Myeloid
/
Genome, Human
/
DNA Methylation
Limits:
Humans
Language:
En
Journal:
Leuk Lymphoma
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
Year:
1998
Document type:
Article
Affiliation country:
Estados Unidos