Image analysis studies of water transport and dimensional changes occurring in the early stages of hydration in cross-linked amylose matrices.
J Control Release
; 52(1-2): 63-70, 1998 Mar 02.
Article
in En
| MEDLINE
| ID: mdl-9685936
ABSTRACT
The purpose of this work was to monitor and quantify water transport and dimensional changes occurring in the early stages of hydration in cross-linked amylose (CLA) matrices using image analysis technique. Samples were prepared by direct compression of CLA-6 powder to obtain matrices of 0.17 cm thickness and 1.295 cm in diameter. A surface gel layer was formed quasiinstantaneously. The gel expansion was then constrained and the material continuity caused the outer gel layer to be in a state of biaxial compression and the internal core in a state of biaxial tension. A diffusion front preceded the gel-glass interface even in the early stages of hydration. A delayed stress-release occurred through a radial expansion of the tablet interior. This relaxation coincided with the time at which the axial diffusion fronts met. The dimensional changes had a marked impact on the kinetics of water uptake in CLA-6 tablets in early stages of hydration.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Amylose
Language:
En
Journal:
J Control Release
Journal subject:
FARMACOLOGIA
Year:
1998
Document type:
Article
Affiliation country:
Canadá