Antioxidative defense in human myocardial reperfusion injury.
J Environ Pathol Toxicol Oncol
; 17(3-4): 281-4, 1998.
Article
in En
| MEDLINE
| ID: mdl-9726803
ABSTRACT
The activity of glutathione peroxidase (GSH-Px) as well as the activities of other antioxidative enzymes such as CuZn superoxide dismutase (CuZn SOD), catalase (CAT), glutathione reductase (GR) in erythrocytes, the plasma activity of glutathione-S-transferase (GST), and the plasma levels of vitamin E and vitamin C were evaluated in nine patients with acute myocardial infarction (AMI). Blood samples were taken before and 1, 3, 6, and 24 hours after the institution of thrombolytic therapy. The results were compared with those in 30 healthy volunteers. A significant decrease in catalase (CAT) activity and vitamin E content in patients before and after thrombolytic therapy as compared with controls was recorded. Our results confirmed that a disturbed oxidative/antioxidative balance is present after AMI and after thrombolytic therapy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Superoxide Dismutase
/
Myocardial Reperfusion Injury
/
Catalase
/
Glutathione Peroxidase
/
Glutathione Reductase
Limits:
Adult
/
Aged
/
Humans
/
Middle aged
Language:
En
Journal:
J Environ Pathol Toxicol Oncol
Journal subject:
NEOPLASIAS
/
PATOLOGIA
/
SAUDE AMBIENTAL
/
TOXICOLOGIA
Year:
1998
Document type:
Article
Affiliation country:
Yugoslavia