Effect of acetylsalicylic acid on formalin test and on serotonin system in the rat brain.
Gen Pharmacol
; 31(5): 753-8, 1998 Nov.
Article
in En
| MEDLINE
| ID: mdl-9809474
ABSTRACT
1. Acetylsalicylic acid (ASA; 400 mg/kg, i.p.) increased serotonin (5-HT) content in rat brain but did not modify the number or the affinity of 5-HT1A receptors in the pons and the cerebral cortex, whereas the number of cortical 5-HT2 receptors decreased significantly. 2. Pretreatment with parachlorophenylaline (100 mg/kg/day for 4 days) depleted 5-HT brain content but modified neither the serum levels of salicylates nor the 5-HT2 cortical receptor characteristics, and it abolished the antinociceptive effect of ASA, 400 mg/kg, in the first phase of the formalin test. 3. These data support the involvement of the central serotonergic system in the antinociceptive activity of ASA.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Serotonin
/
Anti-Inflammatory Agents, Non-Steroidal
/
Aspirin
Limits:
Animals
Language:
En
Journal:
Gen Pharmacol
Year:
1998
Document type:
Article
Affiliation country:
Italia