Effects of endothelin-3 on water and sodium excretion during extracellular volume expansion.
Peptides
; 19(8): 1373-6, 1998.
Article
in En
| MEDLINE
| ID: mdl-9809651
ABSTRACT
The aim of the present study was to elucidate the role of an IV dose of endothelin-3 (ET-3) (5 ng Kg-1 min-1) on mean arterial pressure (MAP), on diuresis and natriuresis in control and in volume expanded anesthetized rats. A systemic infusion of ET-3 in normal rats (Group I) increased MAP and produced a trend of increasing diuresis, without changes in natriuresis. A 10% body weight expansion (Group II) increased diuresis and natriuresis without changes in MAP. The simultaneous infusion of ET-3 and expansion with saline (Group III) resulted in an increase in MAP, an enhanced diuretic response, and a natriuresis of similar magnitude to that observed in Group II. These results suggest that the diuresis produced by a low dose of exogenous ET-3 in control rats, is independent of sodium excretion. Furthermore, the enhanced diuresis caused by ET-3 during expansion is greater than the addition of ET-3 and expansion effects, suggesting that new mechanisms are triggered in order to maintain volume and salt homeostasis in this state.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sodium
/
Water
/
Endothelin-3
/
Extracellular Space
Limits:
Animals
Language:
En
Journal:
Peptides
Year:
1998
Document type:
Article
Affiliation country:
Argentina