Brain mast cells lack the c-kit receptor: immunocytochemical evidence.
J Neuroimmunol
; 90(2): 207-11, 1998 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-9817449
ABSTRACT
Mast cells are reported to differ from other cells of the hematopoietic lineage in that as mature cells, they retain the c-kit receptor, and are thus capable of responding to the stem cell factor (SCF) ligand. SCF is important for development and survival of mast cells. In this study, c-kit expression was examined immunocytochemically in the brains of mice, rats and doves. The results indicate that brain mast cells lack the c-kit receptor; those of the leptomeninges and other connective tissues are a mixed population of c-kit positive and negative cells. The mechanisms whereby brain mast cells might survive in the absence of SCF-c-kit signaling are discussed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Chemistry
/
Proto-Oncogene Proteins c-kit
/
Mast Cells
Limits:
Animals
Language:
En
Journal:
J Neuroimmunol
Year:
1998
Document type:
Article
Affiliation country:
Estados Unidos