Immunohistochemical expression of ABH/Lewis-related antigens in primary breast carcinomas and metastatic lymph node lesions.
Cancer Detect Prev
; 22(6): 499-505, 1998.
Article
in En
| MEDLINE
| ID: mdl-9824372
ABSTRACT
The expression of blood group antigens A, B, and H, as well as sialylated and nonsialylated forms of Lewis(a) and Lewis(x), was studied using immunohistochemical methods in normal and tumor tissues in the following cohort of patients 51 patients with primary breast carcinoma, 13 with metastatic lymph node lesions, and 16 with benign tumors of the breast. As a control, normal tissue was obtained from a similar group of 22 patients with breast cancer. The noncancerous tissues expressed the same A/B/H antigens as the patients' red blood cells and also usually expressed Lewis-related antigens. Seventy-six percent of primary carcinomas failed to express the appropriate A/B/H antigens, and in one blood group A patient the tumor tissue expressed B antigen. In the metastatic lesions, Lewis(a)/sialyl Lewis(a) expression was reduced when compared with the primary tumors, but Lewis(x)/sialyl Lewis(x) antigens were still expressed. These results suggest a possible relationship between the metastatic behavior of the tumor and expression of the blood group antigens.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Lewis Blood Group Antigens
/
Lymph Nodes
/
Neoplasm Metastasis
Limits:
Humans
Language:
En
Journal:
Cancer Detect Prev
Year:
1998
Document type:
Article
Affiliation country:
Japón