Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages.
Bioorg Med Chem Lett
; 8(19): 2711-4, 1998 Oct 06.
Article
in En
| MEDLINE
| ID: mdl-9873608
ABSTRACT
New derivatives with electron-withdrawing substituents at the C-2 position of 3-oxoolean-1-en-28-oic acid were synthesized. Among them, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO) was 400 times more potent than previous compounds we have made as an inhibitor of production of nitric oxide induced by interferon-gamma in mouse macrophages (IC50, 0.4 nM). The potency of CDDO was similar to that of dexamethasone, although CDDO does not act through the glucocorticoid receptor.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oleanolic Acid
/
Macrophages
/
Nitric Oxide
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
1998
Document type:
Article
Affiliation country:
Estados Unidos