Distinct recognition of non-clade B human immunodeficiency virus type 1 epitopes by cytotoxic T lymphocytes generated from donors infected in Africa.
J Virol
; 73(2): 1708-14, 1999 Feb.
Article
in En
| MEDLINE
| ID: mdl-9882385
ABSTRACT
We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several novel non-clade B CTL epitopes, including some restricted by HLA alleles common in Africans. Although cross-clade CTL recognition of these epitopes does occur, recognition can also be highly clade specific.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
T-Lymphocytes, Cytotoxic
/
HIV Infections
/
HIV-1
/
Epitopes, T-Lymphocyte
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Africa
Language:
En
Journal:
J Virol
Year:
1999
Document type:
Article
Affiliation country:
Reino Unido