Homocysteine levels and coronary heart disease in Syria.
J Cardiovasc Risk
; 5(4): 257-61, 1998 Aug.
Article
in En
| MEDLINE
| ID: mdl-9919474
ABSTRACT
BACKGROUND:
Coronary artery disease and disturbances of lipid levels are common in Arab countries.OBJECTIVE:
To assess homocysteine as a cardiovascular risk factor.METHOD:
We compared 133 men with angiographically documented coronary heart disease with 130 age-matched asymptomatic men.RESULTS:
Cases had more hypertension and diabetes and higher levels of total cholesterol, low-density lipoprotein cholesterol, triglycerides, fibrinogen, and homocysteine than did controls. The homocysteine level distribution of cases was shifted toward higher concentrations (P < 0.05) compared with those in controls. When patients with one-vessel, two-vessel, and three-vessel disease were compared, only levels of fibrinogen and homocysteine were associated with the numbers of vessels involved. Homocysteine level was not correlated to fibrinogen and lipid concentrations. A multiple regression analysis revealed that only age (P = 0.06) and smoking (P = 0.04) were marginally related to homocysteine concentrations. Homocysteine concentrations in cases were significantly different than those in controls, even after adjustment for all covariates (P < 0.006).CONCLUSION:
Hyperhomocysteinemia is independently associated with coronary artery disease in Arab men. Furthermore, fibrinogen concentrations are also an important risk factor for Arab men.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coronary Disease
/
Hyperhomocysteinemia
/
Homocysteine
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
J Cardiovasc Risk
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
Year:
1998
Document type:
Article
Affiliation country:
Siria
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM