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Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients
Preprint
in En
| PREPRINT-MEDRXIV
| ID: ppmedrxiv-20125096
ABSTRACT
SARS-CoV-2 outbreak is a world-wide pandemic. The Spike protein plays central role in cell entry of the virus, and triggers significant immuno-response. Our understanding of the immune-response against S protein is still very limited. Herein, we constructed a peptide microarray and analyzed 55 convalescent sera, three areas with rich linear epitopes were identified. Potent neutralizing antibodies enriched from sera by 3 peptides, which do not belong to RBD were revealed.
cc_by_nc_nd
Full text:
1
Collection:
09-preprints
Database:
PREPRINT-MEDRXIV
Language:
En
Year:
2020
Document type:
Preprint