Development of Acute Megakaryoblastic Leukemia with Isochromosome (12p) after a Primary Mediastinal Germ Cell Tumor in Korea
Journal of Korean Medical Science
; : 1099-1102, 2011.
Article
in En
| WPRIM
| ID: wpr-100569
Responsible library:
WPRO
ABSTRACT
The association of hematological malignancies with a mediastinal germ cell tumor (GCT) is very rare. We report one case of a young adult male with primary mediastinal GCT who subsequently developed acute megakaryoblastic leukemia involving isochromosome (12p). A 25-yr-old man had been diagnosed with a mediastinal GCT and underwent surgical resection and adjuvant chemotherapy. At 1 week after the last cycle of chemotherapy, his peripheral blood showed leukocytosis with blasts. A bone marrow study confirmed the acute megakaryoblastic leukemia. A cytogenetic study revealed a complex karyotype with i(12p). Although additional chemotherapy was administered, the patient could not attain remission and died of septic shock. This case was definitely distinct from therapy-related secondary leukemia in terms of clinical, morphologic, and cytogenetic features. To our knowledge, this is the first case report of a patient with mediastinal GCT subsequently developing acute megakaryoblastic leukemia involving i(12p) in Korea.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Shock, Septic
/
Bleomycin
/
Bone Marrow
/
Chromosomes, Human, Pair 12
/
Antineoplastic Combined Chemotherapy Protocols
/
Leukemia, Megakaryoblastic, Acute
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Cisplatin
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Neoplasms, Second Primary
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Neoplasms, Germ Cell and Embryonal
/
Isochromosomes
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2011
Document type:
Article