Increased Expression of Thymosin β₄ Is Independently Correlated with Hypoxia Inducible Factor-1α (HIF-1α) and Worse Clinical Outcome in Human Colorectal Cancer
Journal of Pathology and Translational Medicine
; : 9-16, 2017.
Article
in En
| WPRIM
| ID: wpr-13609
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Thymosin β₄ is a multi-functional hormone-like polypeptide, being involved in cell migration, angiogenesis, and tumor metastasis. This study was undertaken to clarify the clinicopathologic implications of thymosin β₄ expression in human colorectal cancers (CRCs). METHODS: We investigated tissue sections from 143 patients with CRC by immunohistochemistry. In addition, we evaluated the expression patterns and the clinico-pathological significance of thymosin β₄ expression in association with hypoxia inducible factor-1α (HIF-1α) expression in the CRC series. RESULTS: High expression of thymosin β₄ was significantly correlated with lymphovascular invasion, invasion depth, regional lymph node metastasis, distant metastasis, and TNM stage. Patients with high expression of thymosin β₄ showed poor recurrence-free survival (p = .001) and poor overall survival (p = .005) on multivariate analysis. We also found that thymosin β4 and HIF-1α were overexpressed and that thymosin β₄ expression increased in parallel with HIF-1α expression in CRC. CONCLUSIONS: A high expression level of thymosin β₄ indicates poor clinical outcomes and may be a useful prognostic factor in CRC. Thymosin β₄ is functionally related with HIF-1α and may be a potentially valuable biomarker and possible therapeutic target for CRC.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Thymosin
/
Immunohistochemistry
/
Colorectal Neoplasms
/
Cell Movement
/
Multivariate Analysis
/
Lymph Nodes
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Hypoxia
/
Neoplasm Metastasis
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Journal of Pathology and Translational Medicine
Year:
2017
Document type:
Article