Association of acute tubular necrosis with gross hematuria in cirrhosis-related immunoglobulin A nephropathy
Kidney Research and Clinical Practice
; : 43-46, 2013.
Article
in En
| WPRIM
| ID: wpr-142104
Responsible library:
WPRO
ABSTRACT
Immunoglobulin A (IgA) nephropathy associated with cirrhosis is the most common form of secondary IgA nephropathy (IgAN). Cirrhosis-related IgAN is usually clinically silent with a rare occurrence of gross hematuria, unlike in cases of idiopathic IgAN. Especially, acute tubular necrosis (ATN) associated with gross hematuria is very rare in cirrhosis-related IgAN, although acute renal failure is a frequently reported complication in advanced cirrhosis. Herein, we report an unusual case of ATN requiring renal replacement therapy, associated with gross hematuria in a patient with nonalcoholic, hepatitis B virus-associated cirrhosis. Results of a histopathological analysis revealed obstruction of the lumen of renal tubules by red blood cell casts, a marked tubular necrosis, and IgA deposition in the mesangium. The patient's renal function and gross hematuria were clearly improved after lamivudine treatment.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Fibrosis
/
Immunoglobulin A
/
Immunoglobulins
/
Renal Replacement Therapy
/
Lamivudine
/
Erythrocytes
/
Renal Insufficiency
/
Acute Kidney Injury
/
Glomerulonephritis, IGA
/
Hematuria
Limits:
Humans
Language:
En
Journal:
Kidney Research and Clinical Practice
Year:
2013
Document type:
Article