Protective effects of Acanthopanax divaricatus extract in mouse models of Alzheimer's disease
Nutrition Research and Practice
; : 386-390, 2014.
Article
in En
| WPRIM
| ID: wpr-142633
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Acanthopanax divaricatus var. albeofructus (ADA) extract has been reported to have anti-oxidant, immunomodulatory, and anti-mutagenic activity. MATERIALS/METHODS:
We investigated the effects of ADA extract on two mouse models of Alzheimer's disease (AD); intracerebroventricular injection of beta-amyloid peptide (Abeta) and amyloid precursor protein/presenilin 1 (APP/PS1)-transgenic mice.RESULTS:
Intra-gastric administration of ADA stem extract (0.25 g/kg, every 12 hrs started from one day prior to injection of Abeta1-42 until evaluation) effectively blocked Abeta1-42-induced impairment in passive avoidance performance, and Abeta1-42-induced increase in immunoreactivities of glial fibrillary acidic protein and interleukin (IL)-1alpha in the hippocampus. In addition, it alleviated the Abeta1-42-induced decrease in acetylcholine and increase in malondialdehyde levels in the cortex. In APP/PS1-transgenic mice, chronic oral administration of ADA stem extract (0.1 or 0.5 g/kg/day for six months from the age of six to 12 months) resulted in significantly enhanced performance of the novel-object recognition task, and reduced amyloid deposition and IL-1beta in the brain.CONCLUSIONS:
The results of this study suggest that ADA stem extract may be useful for prevention and treatment of AD.Key words
Full text:
1
Database:
WPRIM
Main subject:
Brain
/
Acetylcholine
/
Administration, Oral
/
Interleukins
/
Plaque, Amyloid
/
Eleutherococcus
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Alzheimer Disease
/
Glial Fibrillary Acidic Protein
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Hippocampus
/
Amyloid
Limits:
Animals
Language:
En
Journal:
Nutrition Research and Practice
Year:
2014
Document type:
Article