A Case of Primary Anti-D Alloimmunization by RHD (c.1227G>A) DEL Red Blood Cell Transfusion / 대한수혈학회지
Korean Journal of Blood Transfusion
; : 169-173, 2016.
Article
in Ko
| WPRIM
| ID: wpr-147857
Responsible library:
WPRO
ABSTRACT
The Rh blood group D antigen is the most immunogenic of all antigens, next to ABO antigens. Anti-D immunization is clinically important since it may cause clinical problems, such as severe hemolytic transfusion reactions and hemolytic disease of the newborn. DEL is an extremely weak D variant that cannot be detected by basic serologic typing and is typed as D-negative without the absorption-elution techniques and RHD genotyping. Of the DEL phenotype, RHD (c.1227G>A) allelic variant is the most common in Korea. The DEL phenotype has been considered to carry only a few D antigens to induce anti-D immunization, but a few cases have reported that this allelic variant is capable of inducing anti-D immunization in a D-negative recipient, for which it is clinical significant. Herein, we present a case of primary anti-D alloimmunization in a RhD negative patient after receiving RHD (c.1227G>A) DEL red cell transfusion identified by serological and molecular tests, including RHD genotyping.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Phenotype
/
Immunization
/
Erythrocyte Transfusion
/
Erythrocytes
/
Transfusion Reaction
/
Korea
Limits:
Humans
/
Newborn
Country/Region as subject:
Asia
Language:
Ko
Journal:
Korean Journal of Blood Transfusion
Year:
2016
Document type:
Article