Expression of RUNX3 in Human Gastric Cancer
Journal of the Korean Gastric Cancer Association
; : 185-192, 2007.
Article
in Ko
| WPRIM
| ID: wpr-157795
Responsible library:
WPRO
ABSTRACT
PURPOSE:
RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer. In the present study, we examined the pattern of RUNX3 expression in gastric cancer cells from gastric cancer specimens and the impact of its alteration on clinical outcome. MATERIALS ANDMETHODS:
A total of 124 samples of both gastric cancer and normal tissue were obtained from 124 patients who underwent curative gastrectomy at the Seoul Medical Center from January 2001 to December 2005. RUNX3 expression was determined by immunohistochemical staining, and the results were analyzed. Statistical analysis wabased on clinicopathological findings and differences in survival rates.RESULTS:
The mean age of the patients was 61 years, and the malefemale ratio was 1.91. The expression rate of RUNX3 was 59.7% (74/124). The expression rate was higher in differentiated gastric cancers (nucleus 9.1%, cytoplasm 57.6%) than in the undifferentiated types (nucleus 5.2%, cytoplasm 46.6%) (P=0.133). The 5-year survival rates according to RUNX3 expression determined from cancer tissue were 88.9% for the nucleus +/- cytoplasm(+) group of patients, 76.1% for the cytoplasm only (+) group of patients, and 65.3% for the RUNX3 negative expression group of patients (P=0.626). Only UICC TNM staging showed statistical significance related to the survival rate, as determined by multivariate analysis.CONCLUSION:
The RUNX3 expression rate was higher in differentiated gastric cancer than in the undifferentiated types without significance. Although RUNX3 expression predicted better survival, based on multivariate analysis, the finding was not statistically significant. More cases should be further evaluated.Key words
Full text:
1
Database:
WPRIM
Main subject:
Prognosis
/
Stomach Neoplasms
/
Multivariate Analysis
/
Survival Rate
/
Cytoplasm
/
Seoul
/
Gastrectomy
/
Neoplasm Staging
Type of study:
Prognostic_studies
Limits:
Humans
Country/Region as subject:
Asia
Language:
Ko
Journal:
Journal of the Korean Gastric Cancer Association
Year:
2007
Document type:
Article