Vitamin D Deficiency and Related Factors in Patients at a Hospice / 한국호스피스완화의료학회지
Korean Journal of Hospice and Palliative Care
; : 27-33, 2014.
Article
in Ko
| WPRIM
| ID: wpr-18556
Responsible library:
WPRO
ABSTRACT
PURPOSE: Although vitamin D deficiency is more commonly found in cancer patient than in non-cancer patients, there have been little data regarding the prevalence of vitamin D deficiency in cancer patients at the very end of life. We examined vitamin D deficiency in terminally ill cancer patients and related factors. METHODS: This study was based on a retrospective chart review of 133 patients in a hospice ward. We collected data regarding age, sex, serum 25-hydroxyvitamin D level, cancer type, physical performance, current medications and various laboratory findings. We investigated factors related to serum vitamin D levels after multivariate adjustment for potential confounders. Serum 25-hydroxyvitamin D<20 ng/mL was considered deficient and <10 ng/mL severely deficient. RESULTS: Ninety-five percent of the patients were serum vitamin D deficient. Severe vitamin D deficiency was more common in male patients, non-lung cancer patients, H2 blocker users and non-anticonvulsant users. Elevated levels of serum alanine aminotransferase (ALT) were also associated with low serum vitamin D levels. Multiple regression analysis showed that severe vitamin D deficiency was associated with male gender (aOR 3.82, 95% CI: 1.50~9.72, P=0.005), H2 blocker users (aOR 3.94, 95% CI: 1.61~9.65, P=0.003) and elevated serum ALT levels (aOR 4.52, 95% CI: 1.35~15.19, P=0.015). CONCLUSION: Vitamin D deficiency was highly prevalent among terminally ill cancer patients. Severe vitamin D deficiency was more common in male patients, H2 blocker users, and patients with elevated ALT levels.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Vitamin D
/
Vitamin D Deficiency
/
Prevalence
/
Retrospective Studies
/
Terminally Ill
/
Alanine Transaminase
/
Hospices
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Humans
/
Male
Language:
Ko
Journal:
Korean Journal of Hospice and Palliative Care
Year:
2014
Document type:
Article