Schizophrenia and Glutathione S-transferase P Gene Polymorphism / 신경정신의학
Journal of Korean Neuropsychiatric Association
; : 23-28, 2004.
Article
in Ko
| WPRIM
| ID: wpr-20634
Responsible library:
WPRO
ABSTRACT
OBJECTIVES: This study is aimed to test the association between the coding sequence functional polymorphism (I105 V) of glutathione S-transferase P gene (GSTP1) and schizophrenia. METHODS: Two hundred fourteen (214) patients with schizophrenia according to the DSM-IV criteria and one hundred ten (110) healthy controls were enrolled in this study. Patients and controls were biologically unrelated age and sex- matched native Koreans. Genotyping for the GSTP1 polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: Genotype and allele distributions of the GSTP1 polymorphism in patients with schizophrenia were not significantly different from those of the controls. Comparisons of clinical variables also were not different according to genotype and allele distribution. CONCLUSION: The present study suggests that the GSTP1 polymorphism may not confer susceptibility to development of schizophrenia, at least in the Korean population.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Schizophrenia
/
Diagnostic and Statistical Manual of Mental Disorders
/
Alleles
/
Clinical Coding
/
Genotype
/
Glutathione
/
Glutathione Transferase
Limits:
Humans
Language:
Ko
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2004
Document type:
Article