Membranous Nephropathy after Allogeneic Hematopoietic Stem Cell Transplantation in a Patient with Aplastic Anemia: A Case Report
Journal of Korean Medical Science
; : 287-289, 2003.
Article
in En
| WPRIM
| ID: wpr-210097
Responsible library:
WPRO
ABSTRACT
Nephrotic syndrome has been described as one of the clinical forms of chronic graft-versus-host disease (cGVHD), but a limited number of cases have been described. We experienced a young female patient with nephrotic syndrome developed 22 months after allogeneic hematopoietic stem cell transplantation (HSCT) for severe aplastic anemia. She had been well after successful management for gut-limited cGVHD until she developed a clinical nephrotic syndrome with hypoalbuminemia of 2.0 g/dL and 24-hr urine protein of 6.88 g/dL. On physical examination and laboratory findings, there was no other evidence of cGVHD. Clinical and renal biopsy findings were consistent with cGVHD-related membranous nephropathy, and immunosuppressive agents with cyclosporine and prednisone were prescribed. After 3 month of treatment, the proteinuria decreased to normal range; and the patient from nephrotic syndrome nearly recovered. We recommend cGVHD-related glomerulonephritis should be considered in all patients with hypoalbuminemia following allogeneic HSCT, even if there is no other evidence of clinical GVHD.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Glomerulonephritis, Membranous
/
Hematopoietic Stem Cell Transplantation
/
Graft vs Host Disease
/
Anemia, Aplastic
/
Kidney Glomerulus
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2003
Document type:
Article