Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea
Yonsei Medical Journal
; : 1562-1567, 2014.
Article
in En
| WPRIM
| ID: wpr-221606
Responsible library:
WPRO
ABSTRACT
PURPOSE: This study investigated the possible relationship between viral infection and first trimester pregnancy loss. MATERIALS AND METHODS: A prospective study was performed on 51 gravidas with missed abortion, fetal anomaly, pre-term delivery, and full-tem delivery at Hanyang University Hospital. Enteroviruses were detected by semi-nested reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in abortive tissues and placentas. Enterovirus serotypes were confirmed by genome sequencing. Herpesviruses were detected by PCR. RESULTS: Coxsackievirus B3 (CVB3) was detected in 8 of 14 missed abortion cases, 1 of 27 full-term cases, and none of the 9 pre-term cases. Coxsackievirus B1 (CVB1) was detected in an encephalocele case. Herpes simplex virus type 1 was found in 4 full-term cases, 3 pre-term cases, and none of the missed abortion cases. CONCLUSION: The prevalence of CVB3 was significantly higher in missed abortion cases compared to full-term or pre-term delivery cases. CVB infection may therefore be an important etiological agent of missed abortion.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Placenta
/
Pregnancy Complications, Infectious
/
Pregnancy Trimester, First
/
Uterus
/
Immunohistochemistry
/
Prevalence
/
Prospective Studies
/
Sequence Analysis, DNA
/
Enterovirus B, Human
/
Abortion, Missed
Type of study:
Observational_studies
/
Prevalence_studies
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Asia
Language:
En
Journal:
Yonsei Medical Journal
Year:
2014
Document type:
Article