Glutaminergic neurons expressing c-Fos in the brainstem and amygdala participate in signal transmission and integration of sweet taste / 南方医科大学学报
Journal of Southern Medical University
; (12): 1138-1141, 2011.
Article
in Zh
| WPRIM
| ID: wpr-235178
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To examine the role of glutaminergic neurons in the transmission and integration of the sweat taste information in the brain stem and the amygdala.</p><p><b>METHODS</b>Conscious Sprague-Dawley rats were subjected to oral sweet taste or water (control) stimulations. The activated neurons were identified by detecting c-Fos expression in taste-related brain areas, and the glutaminergic neurons by detecting vesicular glutamate transpoter-3 (VGLUT3).</p><p><b>RESULTS</b>Compared with control group, the rats with oral sucrose solution stimulation exhibited significantly increased c-Fos-expressing and double-labeled neurons in the nucleus of the solitary tract (NST), the parabrachial nucleus (PBN) and the amygdala.</p><p><b>CONCLUSION</b>Neurons in the NST, PBN and amygdala are activated after oral sweet taste stimulation. The sweet taste perception at different levels in the CNS is partly mediated by glutamate.</p>
Full text:
1
Database:
WPRIM
Main subject:
Physiology
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Sucrose
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Brain Stem
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Signal Transduction
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Proto-Oncogene Proteins c-fos
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Rats, Sprague-Dawley
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Solitary Nucleus
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Glutamic Acid
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Cell Biology
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Vesicular Glutamate Transport Proteins
Limits:
Animals
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2011
Document type:
Article