Distribution of hepatitis B virus genotypes and subgenotypes among chronically infected patients in Xinjiang Uighur / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 88-90, 2009.
Article
in Zh
| WPRIM
| ID: wpr-250045
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution of Hepatitis B virus genotypes and subgenotypes among patients with chronic hepatitis B in Xinjiang Uighur.</p><p><b>METHODS</b>The HBV genotypes and subgenotypes were analyzed by PCR-restriction fragment length polymorphism in 109 patients with chronic hepatitis B.</p><p><b>RESULTS</b>Two HBV genotypes, genotype C (45.9%) and genotype C/D (29.4%) were prevalent, genotype B (8.3%) and genotype D (16.5%) were also found in Xinjiang Uighur. Genotype C had two subgenotypes, C1 (54%) and C2 (46%). Genotype B had only one subgenotype, i.e. Ba. The subgenotype C2 was associated with cirrhosis and hepatocellular carcinoma.</p><p><b>CONCLUSION</b>In Uygurs, the most common HBV genotypes were C and C/D, and the subgenotype C2 was associated with cirrhosis and hepatocellular carcinoma.</p>
Full text:
1
Database:
WPRIM
Main subject:
Virology
/
Hepatitis B virus
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Carcinoma, Hepatocellular
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Hepatitis B, Chronic
/
Genetics
/
Genotype
/
Liver Neoplasms
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Hepatology
Year:
2009
Document type:
Article