Role of HPV16/18/45 DNA testing of cervical specimens as a triage testing in cervical cancer screening / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 254-259, 2013.
Article
in Zh
| WPRIM
| ID: wpr-286014
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the clinical performance of careHPV16/18/45 DNA testing of cervical specimens as a triage testing for women with positive findings during the cervical cancer screening.</p><p><b>METHODS</b>Eligible women aged 25-65 years were enrolled from two high-risk communities in Yangcheng County,Shanxi Province.After providing written informed consent on a voluntary base,women underwent questionnaire-based interview,gynecological examination,and sample collection.Hybrid capture 2 technology(HC2),careHPV,Avantage HPV E6 test,and visual inspection with acetic acid(VIA)were conducted as the primary screening tests at the enrollment visit.Women with any positive finding were invited to receive a second VIA and colposcopy.careHPV16/18/45 was performed as a triage testing.Any visible lesion under colposcopy was directly biopsied.Women with pathology confirmed cervical intraepithelial neoplasia grade 2 and worse(CIN2+)were treated with standard procedures.</p><p><b>RESULTS</b>For the self-collected and doctor-collected samples,the application of careHPV16/18/45 as a triage testing decreased the colposcopy referral to 3.2% and 3.1%,respectively.Meanwhile,the sensitivity,specificity,and positive predictive value(PPV)for CIN2+were 50.0%,97.6%,and 26.7% for women with positive self-sampling careHPV results and 63.0%,97.9%,and 34.0% for women with positive doctor-sampling careHPV results.</p><p><b>CONCLUSION</b>careHPV16/18/45 is promising as a triage testing among women with positive screening findings in low-resource settings.</p>
Full text:
1
Database:
WPRIM
Main subject:
Vaginal Smears
/
Virology
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DNA, Viral
/
Uterine Cervical Neoplasms
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Mass Screening
/
Colposcopy
/
Diagnosis
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Human papillomavirus 16
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Human papillomavirus 18
/
Early Detection of Cancer
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Adult
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Aged
/
Female
/
Humans
Language:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Year:
2013
Document type:
Article