Reference value and clinical correlates of soluble ST2 in healthy community-based Chinese population / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 900-903, 2015.
Article
in Zh
| WPRIM
| ID: wpr-317667
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>This study was designed to investigate the plasma level of soluble ST2 (sST2) and related influencing factors, and establish its reference value in the healthy community-based population in Beijing area of China.</p><p><b>METHODS</b>We measured plasma sST2 level by enzyme-linked immunosorbent assay between March 2012 and August 2012 in 1 334 healthy subjects in communities, including 597 males and 737 females. Empiric and quantile regression methods were used to determine the reference range of plasma sST2. A multiple linear regression model was established to analyze the factors that might affect the level of plasma sST2.</p><p><b>RESULTS</b>Gender is the most important factor affecting the plasma level of sST2 in healthy people. Plasma level of sST2 is significantly higher in men than in women (P < 0.01). Within each age strata, i.e. < 45, 45-54, 55-64, ≥ 65 years old, the plasma levels of sST2 were significantly higher in men than age-matched female (all P < 0.01). Age, body mass index (BMI), systolic blood pressure, diastolic blood pressure, and smoking did not affect plasma sST2 level. Reference range of sST2 was 5.7-53.5 µg/L for men and 4.4-42.4 µg/L for women (95% nonparametric reference interval). The one-side upper 95th percentile value of sST2 to discriminate the cardiovascular disease from healthy state was 47.2 µg/L for men and 37.2 µg/L for women.</p><p><b>CONCLUSIONS</b>This study established the normal reference range of plasma sST2 in healthy community-based population. The major influencing factor of sST2 level in healthy population is gender.</p>
Full text:
1
Database:
WPRIM
Main subject:
Reference Values
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Cardiovascular Diseases
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China
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Multivariate Analysis
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Asian People
Type of study:
Prognostic_studies
Limits:
Female
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Humans
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Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Cardiology
Year:
2015
Document type:
Article