Establishment of a new rabbit model of ischemic cerebral infarction by autologous clot embolism / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To establish a convenient method for preparing rabbit models of ischemic cerebral infarction using autologous clot embolism.</p><p><b>METHODS</b>Ischemic cerebral infarction was induced in rabbits by embolizing the middle cerebral artery using autologous clot emboli. Clinical and histological observations were carried out to evaluate the validity of the animal model.</p><p><b>RESULTS</b>Hemiplegia of different severities was observed in the rabbits after the operation. TTC and HE staining of the brain sections confirmed ischemic cerebral infarction 6 h after obstructing the middle cerebral artery with the autologous clot emboli.</p><p><b>CONCLUSION</b>Embolizing the middle cerebral artery using the autologous emboli is convenient to induce focal ischemic cerebral infarction in rabbits. This model has practical value in the study on the mechanism of ischemic cerebrovascular disease and in developing new strategies for prevention and treatment of the relevant diseases in human.</p>