Expression and significance of B7-H1 and its receptor PD-1 in human gastric carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 192-195, 2008.
Article
in Zh
| WPRIM
| ID: wpr-348135
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>The B7-H1/PD-1 co-signaling pathway has recently been found to play a pivotal role in the immune evasion of tumor cells from host immune system. The aim of this study was to examine the B7-H1 and PD-1 expression and TILs status in gastric cancer and to elucidate the clinical relevance of B7-H1 and PD-1 to the pathogenesis of gastric carcinoma.</p><p><b>METHODS</b>Immunohistochemistry and ANAE histochemical staining were used to investigate the in situ expression of B7-H1 and PD-1 and TILs status in the gastric tissues. RT-PCR was used to explore B7-H1 and PD-1 expression at the transcriptional level. The B7-H1 expression at protein level was detected by Western blot.</p><p><b>RESULTS</b>Expression of B7-H1 and PD-1 was found to be increased in gastric carcinoma, but absent in normal gastric tissue. B7-H1 expression in gastric carcinoma was inversely correlated with TILs infiltration. B7-H1 but not PD-1 expression in tumor tissue was significantly correlated with some clinicopathhological variables including depth of invasion, lymph node metastasis and distant metastasis.</p><p><b>CONCLUSION</b>B7-H1 and PD-1 expressions are increased in gastric carcinoma. This signaling pathway may inhibit antitumor immune responses in gastric carcinoma. B7-H1 expression plays a critical role in the pathogenesis of human gastric carcinoma,and might be a promising prognostic marker and therapeutic target in the treatment of this disease.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pathology
/
Stomach Neoplasms
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RNA, Messenger
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CD4-Positive T-Lymphocytes
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Antigens, CD
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Lymphocyte Subsets
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Lymphocytes, Tumor-Infiltrating
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Allergy and Immunology
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Apoptosis Regulatory Proteins
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B7-H1 Antigen
Type of study:
Prognostic_studies
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Oncology
Year:
2008
Document type:
Article