Telomerase activity and telomere length in CD4+,CD8+ and CD19+ lymphocytes from patients with systemic lupus erythematosus / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 534-537, 2005.
Article
in Zh
| WPRIM
| ID: wpr-355167
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the telomerase activity and the telomere length in CD4(+), CD8(+) and CD19(+) lymphocytes from patients with systemic lupus erythematosus (SLE).</p><p><b>METHODS</b>Telomerase activity of CD4(+), CD8(+) and CD19(+) cells from patients with SLE and normal controls was examined by telomeric repeats amplification protocol. Telomere length in those cells was measured by Southern blot method.</p><p><b>RESULT</b>CD4(+), CD8(+) and CD19(+) cells in patients with SLE showed high telomerase activity, but only telomerase activity of CD19(+) cells was significantly higher than that in controls. The length of telomere in CD4(+) and CD8(+) cells was significantly shorter than that in controls, but not in CD19(+) cells.</p><p><b>CONCLUSION</b>Higher telomerase activity in CD19(+) cells and shortened telomere length in CD4(+) and CD8(+) cells of patients with SLE may be associated with pathogenesis of SLE.</p>
Full text:
1
Database:
WPRIM
Main subject:
Lymphocytes
/
CD4-Positive T-Lymphocytes
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Telomere
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CD8-Positive T-Lymphocytes
/
Telomerase
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Antigens, CD19
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Allergy and Immunology
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Genetics
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Lupus Erythematosus, Systemic
/
Metabolism
Limits:
Adolescent
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Adult
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Female
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2005
Document type:
Article