The Role of Skeletal Muscle in Development of Nonalcoholic Fatty Liver Disease
Diabetes & Metabolism Journal
; : 278-285, 2013.
Article
in En
| WPRIM
| ID: wpr-35830
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Nonalcoholic fatty liver disease (NAFLD) is closely correlated with abnormal accumulation of visceral fat, but the role of skeletal muscle remains unclear. The aim of this study was to elucidate the role of skeletal muscle in development of NAFLD.METHODS:
Among 11,116 subjects (6,242 males), we examined the effects of skeletal muscle mass and visceral fat area (VFA, by bioelectric impedance analysis) on NAFLD using by the fatty liver index (FLI).RESULTS:
Of the total subjects (9,565 total, 5,293 males) included, 1,848 were classified as having NALFD (FLI > or =60). Body mass index, lipid profile, fasting plasma glucose, hemoglobin A1c, prevalence of type 2 diabetes (DM), hypertension (HTN), and metabolic syndrome were higher in males than females, but FLI showed no significant difference. The low FLI group showed the lowest VFA and highest skeletal muscle mass of all the groups. Skeletal muscle to visceral fat ratio (SVR) and skeletal muscle index had inverse correlations with FLI, when adjusted for age and gender. In multivariate regression analysis, SVR was negatively associated with FLI. Among SVR quartiles, the highest quartile showed very low risk of NAFLD when adjusted for age, gender, lipid profile, DM, HTN, and high sensitivity C-reactive protein from the lowest quartiles (odds ratio, 0.037; 95% confidence interval, 0.029 to 0.049).CONCLUSION:
Skeletal muscle mass was inversely associated with visceral fat area, and higher skeletal muscle mass may have a beneficial effect in preventing NAFLD. These results suggest that further studies are needed to ameliorate or slow the progression of sarcopenia.Key words
Full text:
1
Database:
WPRIM
Main subject:
Plasma
/
C-Reactive Protein
/
Hemoglobins
/
Body Mass Index
/
Prevalence
/
Fasting
/
Electric Impedance
/
Muscle, Skeletal
/
Intra-Abdominal Fat
/
Fatty Liver
Type of study:
Prevalence_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Diabetes & Metabolism Journal
Year:
2013
Document type:
Article