Effect of PPARγ and glucocorticoid receptor on hepatic glucose metabolism / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
; (12): 430-432, 2012.
Article
in Zh
| WPRIM
| ID: wpr-425933
Responsible library:
WPRO
ABSTRACT
HepG2 cells were incubated with dexamethasone,glucocorticoid receptor (GR) antagonist RU486,and pioglitazone for 24 or 48 h.Glucose concentration in culture medium was detected.The results showed that 10 μmol/L RU486 blocked the surge of glucose concentration by 48 h of dexamethasone treatment and the glucose concentration in RU486 + pioglitazone group was higher than pioglitazone group( P<0.05 ),suggesting that the cross talk between PPARγ and GR may exist in hepatic glucose metabolism.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2012
Document type:
Article