Study of P300 in senile patients with depression: a meta-analysis of domestic literatures / 中华老年医学杂志

ABSTRACT

Objective To assess the latency and amplitude changes in P300 in senile patients with depression.Methods 13 domestic published study literatures meeting our criteria were searched from CBM,CNKI,and a meta-analysis on P300 latency and amplitude was performed with RenMan 4.1 soft ware.Results 1.The P300 latency in senile patients with depression was significant longer than that in senile normal controls in N1,P2,N2,P300 (N1WMD=3.07,95 ％ CI0.7～5.42,Z=2.55,P=0.010;P2WMD=18.41,95％CI15.11～21.71,Z=10.93,P＜ 0.01;N2WMD=25.41,95％CI12.80～29.02,Z=13.80,P＜0.01;P3WMD=32.14,95％CI24.14～34.88,Z=23.04,P＜0.01).2.The amplitude in senile patients with depression was significant lower than that in senile normal controls in N2,P2,P3 (P2WMD=-0.83,95％CI-1.07～-0.59,Z-6.78,P＜0.01; N2WMD＝-0.34,95％CI-0.59～-0.08,Z=2.57,P=0.01;P3WMD=-2.54,95％CI-2.75～-2.33,Z=23.99,P＜0.010).Conclusions P300 longer latency and lower amplitude are the statistically characterized features for senile depressive patients.