A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea
The Korean Journal of Internal Medicine
; : 517-524, 2016.
Article
in En
| WPRIM
| ID: wpr-48500
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS:
The objective of this prospective study was to evaluate the diagnosis and treatment of latent tuberculosis infection (LTBI) in adult close contacts of active pulmonary tuberculosis (TB) patients in Korea.METHODS:
Adult close contacts of active pulmonary TB patients were recruited at a regional tertiary hospital in Korea. The participants were tested for LTBI using the tuberculin skin test (TST) and/or QuantiFERON-TB Gold (QFT-G) test. LTBI patients, who consented to treatment, were randomly assigned to receive isoniazid for 9 months (9INH) or rifampin for 4 months (4RIF).RESULTS:
We examined 189 adult close contacts (> 18 years) of 107 active pulmonary TB patients. The TST and QFT-G were positive (≥ 10 mm) in 75/183 (39.7%) and 45/118 (38.1%) tested participants, respectively. Among 88 TST or QFT-G positive LTBI participants, 45 participants were randomly assigned to receive 4RIF (n = 21) or 9INH (n = 24), respectively. The average treatment duration for the 4RIF and 9INH groups was 3.3 ± 1.3 and 6.1 ± 2.7 months, respectively. Treatment was completed in 25 participants (4RIF, n = 16; 9INH, n = 9). LTBI participants who accepted treatment were more likely to be women and have more cavitary lesions on the chest radiographs of index cases and positive TST and QFT-G results compared to those who refused treatment.CONCLUSIONS:
About 40% of adult close contacts of active pulmonary TB patients had LTBI; about 50% of these LTBI participants agreed to treatment.Key words
Full text:
1
Database:
WPRIM
Main subject:
Rifampin
/
Tuberculin
/
Tuberculosis, Pulmonary
/
Skin Tests
/
Tuberculin Test
/
Radiography, Thoracic
/
Prospective Studies
/
Cohort Studies
/
Diagnosis
/
Latent Tuberculosis
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
The Korean Journal of Internal Medicine
Year:
2016
Document type:
Article