Role of TPMT Genetic Polymorphism in the Individualized Treatment of Thiopurine Drug / 现代检验医学杂志
Journal of Modern Laboratory Medicine
; (4): 1-5,10, 2017.
Article
in Zh
| WPRIM
| ID: wpr-613517
Responsible library:
WPRO
ABSTRACT
Thiopurine S-methyltransferase (TPMT) is an important and key cytoplasmic enzyme in the metabolism of thiopurine drugs,whose activity can directly determine the amount of thiopurine drugs metabolized to cytotoxic 6-thioguanine nucleotides and consequently influence clinical efficacy and adverse drug reactions of thiopurine drugs.In order to deepen knowledge and role of genetic polymorphism of tpmt in the individualized thiopurine drug treatment,this present review mainly covered the following three frequently concerned aspects,including i) whether or not to determine the activity of TPMT priot to treatment of thiopurine drugs;ii) to genotype or to phenotype;iii) how to choose genotype methods.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Journal of Modern Laboratory Medicine
Year:
2017
Document type:
Article