Effect of specific immunotherapy on GM-CSF and IL-5 in the tissues of recurrent nasal polyps / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 2023-2025, 2015.
Article
in Zh
| WPRIM
| ID: wpr-746837
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To study the mechanism and clinical significance of specific immunotherapy (SIT) on the expression changes of GM-CSF and IL-5 in the tissue samples of recurrent nasal polyps.@*METHOD@#Perennial allergic rhinitis patients with recurrent nasal polyps were randomly divided into 2 groups. The experimental group of 19 patients was treated by SIT and standardized treatment (glucocorticoid nasal spray) , and the control group of 17 patients was only treated by standardized treatment (glucocorticoid nasal spray). We measured the expression levels of GM-CSF and IL-5 in the tissue samples of the nasal polyps by ELISA, and compared the results obtained before treatment with expression levels detected at 6 months and 1 year after the treatment.@*RESULT@#The expression of GM-CSF and IL-5 in the recurrent nasal polyps reduced significantly (P < 0.05) in both groups after 6 months and 1 year post-treatment compared with pre-treatment, and the expression of GM-CSF and IL-5 in the experimental group was much lower than that of the control group.@*CONCLUSION@#SIT decreases the expression of GM-CSF and IL-5 and reduces the inflammatory reaction in the tissue samples of recurrent nasal polyps.
Full text:
1
Database:
WPRIM
Main subject:
Pathology
/
Enzyme-Linked Immunosorbent Assay
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Rhinitis, Allergic, Perennial
/
Nasal Polyps
/
Granulocyte-Macrophage Colony-Stimulating Factor
/
Interleukin-5
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Drug Therapy
/
Immunotherapy
/
Inflammation
/
Metabolism
Limits:
Humans
Language:
Zh
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2015
Document type:
Article