Effect and safety analysis of Allergovit standardized mite allergen immunotherapy in patients with allergic rhinitis / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 1128-1131, 2013.
Article
in Zh
| WPRIM
| ID: wpr-747192
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To evaluate the effect and safety analysis of Allergovit standardized dust mite subcutaneous immunotherapy in patients with allergic rhinitis.@*METHOD@#From Jan 2006 to Jan 2009,425 patients with persistent were treated with Allergovit standardized dust mite allergen in 3 years, which data were retrospectively analyzed. The scores of the rhinoconjunctivitis quality of life were collected per-treatment and three years treatment. VAS (visual analogue scale) of all nasal symptoms and drug use scores were evaluated before treatment and every 6 weeks. The frequency of local and systemic reactions were recorded in the duration of dose escalation and maintenance.@*RESULT@#The Overall QOL were significantly improved after 3 years treatment [pre-treatment 3.8 (2.9; 4.5); post-treatment 1.1 (1.0; 2.0), P < 0.01]. VAS of all nasal symptoms and drug used scores decreased dramatically after escalation period [pro-treatment 23. 7 (20.5; 27.8), 3.9 (3.2; 4.7); post-treatment 2.1 (1.6; 2.2), 0(0;0), P < 0.01]. Local reaction's rate was 3.15%, the frequency systemic reaction's rate was 0.90%.@*CONCLUSION@#The standardized specific allergen immunotherapy for allergic rhinitis is safe and effective.
Full text:
1
Database:
WPRIM
Main subject:
Quality of Life
/
Therapeutics
/
Vaccines
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Rhinitis, Allergic, Perennial
/
Retrospective Studies
/
Treatment Outcome
/
Pyroglyphidae
/
Therapeutic Uses
/
Allergy and Immunology
/
Rhinitis, Allergic
Type of study:
Observational_studies
Aspects:
Patient_preference
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2013
Document type:
Article