Effect of escitalopram in the treatment of alcohol-dependent patients with depression / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
; (12): 2220-2223, 2019.
Article
in Zh
| WPRIM
| ID: wpr-753773
Responsible library:
WPRO
ABSTRACT
Objective To observe the clinical effect of escitalopram in the treatment of alcohol -dependent patients with depressive symptoms and its influence on social function recovery .Methods From January 2016 to December 2017,80 alcohol -dependent patients with depressive symptoms in the Seventh People 's Hospital of Wenzhou were selected and divided into two groups by random digital table method ,with 40 cases in each group.The observation group was treated with escitalopram.The control group was treated with placebo for 2 months.The scores of depression,social dysfunction screening scale , quality of life and incidence of adverse reactions were compared between the two groups.Results After treatment for 1 month and 2 months,the depression scores of the observation group were (15.02 ±2.23)points and (9.02 ±2.12)points,respectively,which were lower than those of the control group[(20.13 ±2.12) points,(15.24 ±2.15) points] ( t =10.504,13.029,all P <0.05).After treatment for 1 month and 2 months,the scores of the screening scale for social functional defects in the observation group were (2.85 ±1.23)points and (0.89 ±0.52)points,respectively,which were lower than those in the control group [(4.13 ± 1.62)points,(2.52 ±1.16)points]( t=3.930,8.110,all P<0.05).The scores of physical health ,mental health, physical life,social function and total quality of life in the observation group were (87.47 ±5.69) points,(84.63 ± 5.21)points,(87.16 ±5.24) points,(85.46 ±5.95) points and (86.12 ±5.95) points,respectively,which were higher than those of the control group [(79.58 ±5.93)points,(76.72 ±7.82)points,(79.28 ±5.57)points,(75.92 ± 5.45) points,(78.46 ±5.85) points] (t=5.995,5.257,6.435,7.384,5.733,all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Escitalopram in the treatment of alcohol -dependent patients with depressive symptoms has good effect ,not only helps to improve the depression,but also helps to promote the recovery of social function of the patients ,and the safety is relatively high.
Full text:
1
Database:
WPRIM
Type of study:
Clinical_trials
Aspects:
Patient_preference
Language:
Zh
Journal:
Chinese Journal of Primary Medicine and Pharmacy
Year:
2019
Document type:
Article