Clinical Significance of Additional Chromosomal 8 Clonal Evolution in CML Progression / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1598-1603, 2018.
Article
in Zh
| WPRIM
| ID: wpr-773050
Responsible library:
WPRO
ABSTRACT
OBJECTIVES@#To explore the clinical significance of clonal evolution of additional chromosomal 8 in CML progression.@*METHODS@#An unusual case with the clonal evolution from trisomy 8 to tetrasomy 8 accompanied by 2 time of CML blast crisis (BC) was reported.@*RESULTS@#This patient suffered from 2 time of CML blast crisis and the additional chromosome 8 aberrations were accompanied. Trisomy 8 and tetrasomy 8 were detected at first CML blast crisis and second CML blast crisis, respectively. After tetrasomy 8 was developed, the c-Myc was over-expressed and the central nervous system leukemia happened in this case. Only high dose Ara-C and MTX regimen could induce remission for a short period.@*CONCLUSION@#These findings suggested that additional chromosome 8 aberrations are important marker for poor prognosis of CML patients and contribute to a poor prognosis.
Full text:
1
Database:
WPRIM
Main subject:
Chromosomes, Human, Pair 8
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Blast Crisis
/
Chromosome Aberrations
/
Disease Progression
/
Clonal Evolution
Type of study:
Prognostic_studies
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2018
Document type:
Article