Effects of postconditioning with N,N,N'N'-tetrakis-2-pyridylmethyl-ethylenediamine in isolated rat hearts / 대한마취과학회지
Korean Journal of Anesthesiology
; : 290-295, 2010.
Article
in En
| WPRIM
| ID: wpr-78792
Responsible library:
WPRO
ABSTRACT
BACKGROUND: It was reported that N,N,N'N'-tetrakis-[2-pyridylmethyl]-ethylenediamine (TPEN), a transition metal chelator, confers cardioprotection against myocardial ischemic injury. In this study, we investigated the effect of TPEN targeting reperfusion period in isolated rat hearts. METHODS: Langendorff perfused rat hearts were subjected to 30 min of regional ischemia and 2 h of reperfusion. Hearts were randomly assigned to either control (n = 9) or 10 micrometer of TPEN (n = 8) groups. TPEN was perfused for a period of 5 min before and 30 min after reperfusion. RESULTS: The ratio of infarct area/ischemic area (AN/AR) was significantly reduced in TPEN treated hearts (6.9 +/- 1.7%, P 0.05). CONCLUSIONS: Pharmacological postconditioning with TPEN reduces myocardial infarction however, TPEN does not modify post-ischemic systolic dysfunction in isolated rat hearts.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Reperfusion
/
Reperfusion Injury
/
Myocardial Stunning
/
Ethylenediamines
/
Heart
/
Ischemia
/
Myocardial Infarction
Limits:
Animals
Language:
En
Journal:
Korean Journal of Anesthesiology
Year:
2010
Document type:
Article