Research advances in the association between NF-κB signaling pathway and hepatitis C virus infection / 医学研究生学报

ABSTRACT

The nuclear factor-κB (NF-κB) pathway plays an important role in cell proliferation, survival, early viral response, cytokine secretion, and pro-inflammatory. Hepatitis C virus (HCV) can hijack and interact with the NF-κB signaling pathway and affect disease outcomes. This paper describes the interaction between NF-κB protein family, signaling pathway, HCV viral protein and host NF-κB signaling pathway, and its effect on HCV infection. In the future, further study is expected to be done in this aspect to provide new strategies for the screening of HCV high-susceptibility population as well as prevention.