Research advances in the pathogenesis of non-alcoholic fatty liver mediated by intestinal flora / 解放军医学杂志

ABSTRACT

Non-alcoholic fatty liver disease (NAFLD) has become a common chronic liver disease in the world. Most patients with NAFLD will progress to non-alcoholic steatohepatitis (NASH), and then to liver cirrhosis and hepatocellular carcinoma. The microbial analysis method can be used to explore the changing rules of intestinal flora leading to NAFLD and NASH. Studies have shown that intestinal flora leads to NAFLD by interfering with the enterohepatic axis, intestinal barrier function, and liver steatosis, and as a result, intestinal flora is considered as a potential target for clinical treatment of NAFLD. The purpose of this research is to review the microbe-host interactions associated with the pathogenesis of NAFLD, the mechanism of how intestinal flora is involved in the pathogenesis of NAFLD, and the potential therapeutic effects of regulating intestinal flora on NAFLD.