Difference analysis of myeloid leukemia fusion oncogene expression network based on time series / 中华疾病控制杂志
Chinese Journal of Disease Control & Prevention
; (12): 274-277,289, 2020.
Article
in Zh
| WPRIM
| ID: wpr-873501
Responsible library:
WPRO
ABSTRACT
@#Objective Focusing on four types acute myeloid leukemia ( AML) fusion oncogenes,so as to explore the network difference with time series expression data and further identify important genes in networks. Methods Gene network difference analysis was conducted while focusing on the global attributes of the union network. The CompNet neighborhood similarity index ( CNSI) was adopted to assess network similarity.“fast-greedy”algorithm was used to detect communities based on the union network,and further identify hub genes. Results The CNSI value between NUP98-HOXA9-3 d and NUP98-HOXA9-8 d was 0. 73,while AML1-ETO-6 h and PML-RARA-6 h was 0.25. We identified ten AML associated genes and sev- en of them ( TNF,VEGFA,EP300,EGF,CD44,PTGS2,SMAD3) were reported in the literature. Conclu- sions The network difference analysis revealed the pattern and heterogeneity of AML gene expression change across different time points,and further provided target genes for efficient treatment of AML with different types of fusion oncogenes.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Disease Control & Prevention
Year:
2020
Document type:
Article