Pathogenesis and multidisciplinary management of medication-related osteonecrosis of the jaw / 国际口腔科学杂志·英文版
International Journal of Oral Science
; (4): 30-30, 2020.
Article
in En
| WPRIM
| ID: wpr-880846
Responsible library:
WPRO
ABSTRACT
Medication-related osteonecrosis of the jaw (MRONJ) is a serious side effect of bone-modifying agents and inhibits angiogenesis agents. Although the pathogenesis of MRONJ is not entirely clear, multiple factors may be involved in specific microenvironments. The TGF-β1 signalling pathway may have a key role in the development of MRONJ. According to the clinical stage, multiple variables should be considered when selecting the most appropriate treatment. Therefore, the prevention and management of treatment of MRONJ should be conducted in patient-centred multidisciplinary team collaborative networks with oncologists, dentists and dental specialists. This would comprise a closed responsibility treatment loop with all benefits directed to the patient. Thus, in the present review, we aimed to summarise the pathogenesis, risk factors, imaging features, clinical staging, therapeutic methods, prevention and treatment strategies associated with MRONJ, which may provide a reference that can inform preventive strategies and improve the quality of life for patients in the future.
Full text:
1
Database:
WPRIM
Main subject:
Quality of Life
/
Risk Factors
/
Bone Density Conservation Agents
/
Bisphosphonate-Associated Osteonecrosis of the Jaw
Type of study:
Etiology_studies
/
Risk_factors_studies
Aspects:
Patient_preference
Limits:
Humans
Language:
En
Journal:
International Journal of Oral Science
Year:
2020
Document type:
Article