Progress on the mechanism and intervention of glutamate AMPA receptor GluA2/TARPγ-8 in the pathogenesis of epilepsy / 国际儿科学杂志
International Journal of Pediatrics
; (6): 455-458, 2021.
Article
in Zh
| WPRIM
| ID: wpr-907257
Responsible library:
WPRO
ABSTRACT
Epilepsy occurs as a result of episodic abnormal synchronous discharges in cerebral neuronal networks.It is characterized by an imbalance between excitatory and inhibitory neurotransmission.Although various non-conventional mechanisms are implicated in epileptic synchronization, glutamate excitatory neurons play an essential role.AMPA receptors mediate fast synaptic excitation within and between brain regions relevant to epilepsy, and play a role in epileptogenesis and in seizure-induced brain damage.However, direct modulation of AMPA receptors may have undesirable consequences, given its wide expression within the central nervous system and critical roles on brain circuitry development.Hippocampal CA1 region, as the main site of epilepsy, selectively regulates the high expression of AMPA receptor GluA2 subunit and transmembrane AMPA receptor regulatory protein family(TARPs)γ-8 subtype and its complex GluA2/TARPγ-8, whether it can produce anti-epileptic and avoid adverse reactions.
Full text:
1
Database:
WPRIM
Type of study:
Etiology_studies
Language:
Zh
Journal:
International Journal of Pediatrics
Year:
2021
Document type:
Article