Progress in the pathogenesis of congenital bicuspid aortic valves and the associated complications / 国际儿科学杂志
International Journal of Pediatrics
; (6): 507-510, 2021.
Article
in Zh
| WPRIM
| ID: wpr-907267
Responsible library:
WPRO
ABSTRACT
Congenital bicuspid aortic valves(BAV)is one of the most common congenital heart diseases.It is generally diagnosed by echocardiography when deterioration of the abnormal leaflets becomes clinically evident.Patients with BAV are at increased risks of developing serious complications, including aortic stenosis, aortic regurgitation, aortic dilation, aortic dissection and/or aneurysm, which seriously threatens the health of patients.Although its diagnosis and surgical treatment have been clear, the specific pathogenesis has not been completely revealed.Recently, studies have found that gene mutations and related signaling pathway abnormalities are associated with BAV and its complications.And epigenetics and environmental factors are involved in the development and progress of BAV.Understanding the underlying cellular and molecular basis of normal and pathological aortic valve development may improve the preventative and therapeutic approaches to valve degeneration.
Full text:
1
Database:
WPRIM
Type of study:
Etiology_studies
Language:
Zh
Journal:
International Journal of Pediatrics
Year:
2021
Document type:
Article