Relationship of single nucleotide polymorphisms and genetic susceptibility to sepsis / 中华危重病急救医学
Chinese Critical Care Medicine
; (12): 630-632, 2021.
Article
in Zh
| WPRIM
| ID: wpr-909374
Responsible library:
WPRO
ABSTRACT
Sepsis is a clinical syndrome caused by the host reaction disorder induced by infection, which leads to serious organ function damage. Sepsis is a serious disease with high mortality, which is the main reason of death caused by infection. Single nucleotide polymorphisms (SNP) is one of the most common genetic variants in human, and is closely related to the genetic susceptibility, early diagnosis, disease development and prognosis of sepsis. This article makes a review on the relationship between CD14, Toll like receptor (TLR), tumor necrosis factor (TNF), interleukins (IL-1 and IL-6), plasminogen activator inhibitor 1 (PAI-1), angiotensin converting enzyme (ACE) and other gene polymorphisms and genetic susceptibility of sepsis, in order to affect in sepsis on the early prediction, diagnosis, and treatment.
Full text:
1
Database:
WPRIM
Type of study:
Prognostic_studies
/
Screening_studies
Language:
Zh
Journal:
Chinese Critical Care Medicine
Year:
2021
Document type:
Article