Bioactive neolignans and lignans from the roots of Paeonia lactiflora / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 210-214, 2022.
Article
in En
| WPRIM
| ID: wpr-929253
Responsible library:
WPRO
ABSTRACT
Two new neolignans and one new lignan (1-3) were obtained from the roots of Paeonia lactiflora. Their structures were unambiguously elucidated based on extensive spectroscopic analysis, single-crystal X-ray crystallography, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 was a racemic mixture and successfully resolved into the anticipated enantiomers via chiral-phase HPLC. Compound 3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1 (hCES2A1) with an IC50 value of 7.28 ± 0.94 μmol·-1.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Stereoisomerism
/
Chromatography, High Pressure Liquid
/
Lignans
/
Plant Roots
/
Paeonia
Limits:
Humans
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2022
Document type:
Article