Acute Onset Methimazole-Induced Arthralgia and Skin Rash / 대한갑상선학회지
Journal of Korean Thyroid Association
; : 83-87, 2014.
Article
in Ko
| WPRIM
| ID: wpr-93336
Responsible library:
WPRO
ABSTRACT
Methimazole, a type of thionamide, is used to treat hyperthyroidism. Several adverse effects of thionamides have been reported. The representative minor adverse effects are arthralgia, skin rash, and gastric intolerance. Methimazole is reported to induce 1-6% of arthralgia cases. These patients begin to suffer from arthralgia from 1 month to 2 years after methimazole treatment. Here, we present a patient with acute onset methimazole-induced arthralgia and skin rash. At 2 days after starting methimazole treatment, a 57-year-old female developed arthralgia and a skin rash on her right leg, which subsequently spread to her left leg and right arm, and she stopped taking the medication. The patient was admitted to the rheumatology department of Ulsan University Hospital, where laboratory tests and a skin biopsy were performed to ascertain whether she had a rheumatic disorder. The skin biopsy revealed nonspecific inflammation. At 2 days after stopping methimazole treatment, the arthralgia and skin rashes had improved and methimazole treatment was recommenced. However, the same symptoms developed within 1 day. Therefore, methimazole treatment was again stopped and the symptoms disappeared.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Arm
/
Rheumatology
/
Skin
/
Biopsy
/
Arthralgia
/
Exanthema
/
Hyperthyroidism
/
Inflammation
/
Leg
/
Methimazole
Limits:
Female
/
Humans
Language:
Ko
Journal:
Journal of Korean Thyroid Association
Year:
2014
Document type:
Article