Research progress of optic atrophy 1-mediated mitochondrial dynamics in skeletal system diseases / 中国修复重建外科杂志
Chinese Journal of Reparative and Reconstructive Surgery
; (12): 758-763, 2023.
Article
in Zh
| WPRIM
| ID: wpr-981665
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To review the research progress of mitochondrial dynamics mediated by optic atrophy 1 (OPA1) in skeletal system diseases.@*METHODS@#The literatures about OPA1-mediated mitochondrial dynamics in recent years were reviewed, and the bioactive ingredients and drugs for the treatment of skeletal system diseases were summarized, which provided a new idea for the treatment of osteoarthritis.@*RESULTS@#OPA1 is a key factor involved in mitochondrial dynamics and energetics and in maintaining the stability of the mitochondrial genome. Accumulating evidence indicates that OPA1-mediated mitochondrial dynamics plays an important role in the regulation of skeletal system diseases such as osteoarthritis, osteoporosis, and osteosarcoma.@*CONCLUSION@#OPA1-mediated mitochondrial dynamics provides an important theoretical basis for the prevention and treatment of skeletal system diseases.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Osteoarthritis
/
Osteoporosis
/
Mitochondrial Dynamics
/
GTP Phosphohydrolases
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Reparative and Reconstructive Surgery
Year:
2023
Document type:
Article