Coma criterion and classification standard of mild and moderate traumatic brain injury in rats / 法医学杂志
Journal of Forensic Medicine
; (6): 8-11, 2008.
Article
in Zh
| WPRIM
| ID: wpr-983344
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To set up a classification standard of mild and moderate traumatic brain injury, for the purpose of reliable data comparison derived from different laboratories.@*METHODS@#Traumatic brain injury (TBI) in rats was prepared by using a metallic pendulum-striker device. After injury, five variable parameters including the time of apnea and the areflexia, time of corneal reflex, external auditory canal stung reaction, body-righting reflex and needling reaction were determined and scored by using rat coma criterion. These data were judged and classified into mild and moderate head injury by brain patho-anatomy changes. Then the data were used to set up a multivariate discriminate equation.@*RESULTS@#The distinguished probability of mild and moderate TBI according to actual direct measured value and the criterion were 88.9% and 91.9%, respectively.@*CONCLUSION@#This method is able to classify mild and moderate TBI in rats.
Full text:
1
Database:
WPRIM
Main subject:
Brain Injuries
/
Rats, Sprague-Dawley
/
Coma
/
Forensic Medicine
Limits:
Animals
Language:
Zh
Journal:
Journal of Forensic Medicine
Year:
2008
Document type:
Article