Progress on epigenetics applications in forensic science / 法医学杂志
Journal of Forensic Medicine
; (6): 366-370, 2012.
Article
in Zh
| WPRIM
| ID: wpr-983764
Responsible library:
WPRO
ABSTRACT
Epigenetics is the study of heritable changes in gene expression other than changes in the underlying DNA sequence. Such changes include DNA methylation, histone modification, chromatin remodeling, genomic imprinting, X chromosome inactivation and non-coding RNA regulation. Recent progresses on epigenetics open new possibilities in tackling these challenging problems in forensic science, including identification of fetal paternity testing in embryonic period, determination of the necessary allele in paternity testing, discrimination of identical twins, origination analysis of micro tissue, verification of forged DNA. This review focuses on epigenetics concept and its latest application in the field of paternity testing, age estimation, discrimination between the twins, identification of tissue of origin, and estimation of postmortem interval.
Full text:
1
Database:
WPRIM
Main subject:
Twins, Monozygotic
/
Gene Expression
/
Genomic Imprinting
/
DNA Methylation
/
Epigenesis, Genetic
/
Forensic Sciences
/
Alleles
/
Epigenomics
Limits:
Humans
Language:
Zh
Journal:
Journal of Forensic Medicine
Year:
2012
Document type:
Article